Whole‐genome methylation analysis of aging human tissues identifies age‐related changes in developmental and neurological pathways

Age-associated changes in the DNA methylation state can be used to assess pace of aging. However, it is not understood what mechanisms drive these and whether affect development aging phenotypes process general. This study was aimed at gaining a more comprehensive understanding aging-related across whole genome, relating biological functions. It has been shown that skeletal muscle blood monocytes undergo typical with Using whole-genome bisulfite sequencing, we sought characterize genome-wide derived from both monocytes, link specific genes pathways through enrichment analysis. We found occur locations enriched for developmental neuronal regulated two peripheral tissues. These results contribute our epigenome human